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MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:

1. A 76-year-old man with a 17-year history of type 2 diabetes mellitus attended for his annual review. Comparison of his retinal screening report with the previous year's report showed that his visual acuity was unchanged at 6/9 in both eyes. The previous year's right eye retinal image had been reported as 'pre-proliferative retinopathy', whereas this year's was reported as 'pre-proliferative retinopathy with maculopathy'.
What is the most appropriate next step?

A) routine referral to an ophthalmologist
B) routine re-screen in 6 months
C) routine re-screen in 12 months
D) urgent referral to an ophthalmologist within 2 weeks
E) urgent re-screen within 2 weeks


2. A 24-year-old woman was referred with an 18-month history of worsening hirsutism, primarily on her face, but also new hair growth on her chest. She was shaving weekly. She had always been overweight, but had recently gained 5 kg and her body mass index was 31 kg/m2 (18-25). Her periods were regular.
What is the most relevant next investigation?

A) serum 17-hydroxyprogesterone
B) overnight dexamethasone suppression test (after 1 mg dexamethasone)
C) serum testosterone
D) serum dehydroepiandrosterone
E) plasma thyroid-stimulating hormone


3. A 76-year-old woman with type 2 diabetes mellitus was reviewed. Treatment with thiazolidinedione was being considered, but she was worried about the effect this medication might have on the incidence of complications. She had known background retinopathy.
What complication is more likely to worsen in a patient taking a thiazolidinedione?

A) retinal vein thrombosis
B) macular oedema
C) hard exudates
D) cataract
E) retinal haemorrhages


4. A 46-year-old Afro-Caribbean man with sarcoidosis was found to have hypercalcaemia and was treated with prednisolone 20 mg/day. Within 3 weeks his serum calcium had fallen to within the reference range.
How do glucocorticoids reduce serum calcium in sarcoidosis?

A) increase intravascular fluid volume
B) reduces extrarenal 1-?-hydroxylase activity
C) promote urinary calcium excretion
D) direct calcium shift into cells
E) suppress parathyroid hormone secretion


5. A 62-year-old woman was referred with difficulty in swallowing and a painful, swollen neck.
On examination, her neck was tender to palpation with a small, diffuse goitre. There was no
associated neck lymphadenopathy.
Investigations:
serum thyroid-stimulating hormone<0.04 mU/L (0.4-5.0)
serum free T426.0 pmol/L (10.0-22.0)
serum free T312.0 pmol/L (3.0-7.0)
What is the most likely diagnosis?

A) subacute thyroiditis
B) thyroid carcinoma
C) toxic adenoma
D) haemorrhage into a thyroid cyst
E) Graves' disease


Solutions:

Question # 1
Answer: A
Question # 2
Answer: C
Question # 3
Answer: B
Question # 4
Answer: B
Question # 5
Answer: A

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