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- Total Questions: 175
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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:
1. A 59-year-old patient who is HIV-positive is receiving darunavir and ritonavir as part of a highly active antiretroviral therapy program. Which herbal supplement is contraindicated for this patient because it would decrease darunavir concentrations?
A) Saw palmetto
B) Kava kava
C) Echinacea
D) St. John's wort
2. A 58-year-old patient is admitted to the hospital with a temperature of 38.3°C, cough, and dyspnea. Rales are present at the left base, and chest X-ray reveals a left lower lobe infiltrate.
Oxygen saturation is 88% on room air. Which of the following antibiotics is most appropriate?
A) Levofloxacin
B) Ceftriaxone
C) Azithromycin
D) Doxycycline
3. A patient in an ICU has been receiving heparin 5,000 units subcutaneously three times daily for the last 7 days. Today the patient's platelet count has dropped by more than 50%, and the patient has developed a pulmonary embolism. The patient's heparin platelet factor 4 antibody test is positive.
What is the most appropriate treatment for this patient's pulmonary embolism?
A) Argatroban 2 mcg/kg/min intravenously
B) Dabigatran 150 mg orally twice daily
C) Unfractionated heparin 18 units/kg/h intravenously
D) Warfarin 5 mg orally once daily
4. A patient asks for advice relative to an herbal supplement to treat heart failure. The patient is currently NYHA Class III (LVEF 25%) and is adherent to medications, which include digoxin
0.25 mg daily, furosemide 40 mg daily, lisinopril 10 mg daily, carvedilol 6.25 mg twice daily, potassium 20 mEq daily, and simvastatin 40 mg nightly.
The patient has BP of 120/78 mm Hg, HR of 60 bpm, 9 cm JVD, 2+ pitting edema, and has experienced a 2.3 kg weight gain in last 2 days. All laboratory values are within normal limits.
Based on the following information, what is the most appropriate suggestion for the patient?
A) Omega-3-fatty acid
B) L-Carnitine
C) Avoidance of dietary supplements
D) Coenzyme Q10
5. Many clinically important adverse drug reactions (ADRs) are detected after the marketing of a drug, rather than during premarketing clinical trials. Of the following, which is the primary reason for this phenomenon?
A) Premarketing studies focus on efficacy rather than on safety; therefore, the study design accounts for the failure to detect ADRs.
B) Too few patients are studied for too short a period of time during premarketing clinical trials.
C) Pharmaceutical companies prefer to market agents with favorable side-effect profiles, so they focus premarketing studies on efficacy rather than on ADRs.
D) Adverse reactions that are due to drug interactions or drug accumulation in renal insufficiency cannot be studied prospectively during the premarketing phase of clinical evaluation.
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: C | Question # 3 Answer: C | Question # 4 Answer: A | Question # 5 Answer: B |
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